Mk regimen advisor
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MK REGIMEN ADVISOR is a trademark of Mary Kay Inc. Filed in June 28 (2025), the MK REGIMEN ADVISOR covers DOWNLOADABLE SOFTWARE APPLICATIONS IN THE Mk Regimen Advisor is a Trademark by Mary Kay Inc, the address on file for this trademark is Dallas Parkway, Addison, TX
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(33%) (p = 0.42) (Fig. 4B).Fig. 4Preferred TNT regimens for each ESMO rectal cancer risk category, A all participants, B–D by specialistFull size imageBad riskThe proportion of specialists preferring TNT increased for bad-risk rectal cancer as 76% (22/29) favoured TNT compared to 24% for LCCRT. There was no significant difference between CRS, RO and MO—at least 70% of each preferred TNT for this risk category (p = 0.75) (Fig. 3D). The most selected TNT paradigm was again a consolidation-type regimen, chosen by 55% (16/29). Twenty-one percent preferred an induction regimen, 14% PRODIGE-23 and 10% a RAPIDO or STELLAR regimen. The majority (> 60%) of CRS and RO preferred a consolidation TNT strategy whilst MO preferences were again divided across the TNT regimens (p = 0.60) (Fig. 4C).Advanced riskThere was almost an entire agreement amongst participants that TNT was the preferred approach for advanced-risk rectal cancer as selected by 94% (29/31) of specialists, with no significant difference between CRS, RO or MO (p = 0.29) (Fig. 3E). With regard to the preferred TNT sequence, 69% (20/29) opted for a consolidation-type regimen, 14% for a RAPIDO or STELLAR regimen, 10% induction and 7% PRODIGE-23. The majority (> 60%) of each specialty preferred a consolidation regimen (p = 0.98) (Fig. 4D).DiscussionThe majority of specialists in this survey preferred a TNT strategy for advanced- and bad-risk category rectal cancers, which is supported by strong evidence from the major phase 3 TNT trials. Although TNT data has demonstrated improvements in complete response rates and DFS, our study clearly indicates that TNT is not mandated for all patients. In fact, the overwhelming majority of specialists preferred upfront surgery for early-risk, stage II and III rectal tumours. Meanwhile, the intermediate-risk category provoked the most heterogeneous responses from participants although approximately half opted for TNT. Overall, this survey showed that TNT is not a universal approach to LARC but rather a strategy that can be employed selectively to higher-risk patients on an individualized basis.Across the intermediate, bad, and advanced-risk categories, a consolidation-type TNT regimen, such as that employed in the OPRA and CAO/ARO/AIO-12 trials, was consistently preferred in
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A modified post-transplant cyclophosphamide (PTCy) regimen with a reduction in dose of 40 mg on days +3 and +4 may be effective in patients with severe aplastic anemia (SAA) undergoing unrelated donor allogeneic hematopoietic stem cell transplantation (URD-HSCT), while reducing the occurrence of graft vs host disease (GVHD), according to a study published in Transplantation and Cellular Therapy. Current guidelines recommend that allo-HSCT be performed from a human leukocyte antigen (HLA)-matched sibling donor; in the event that this is unavailable, treatment with immunosuppressive therapy is first recommended, failure of which allo-HSCT from URDs may be considered. Prior research has shown that the PTCy regimen is effective in reducing the risk of GVHD; furthermore, this regimen is associated with improved prognosis. The study authors sought to assess the clinical outcomes of patients with SAA who received PTCy regimens for the URT HSCT procedure. From July 2019 to June 2022, 30 patients with SAA who underwent URT HSCT and were on a modified PTCy regimen treated at the Guangzhou First People’s Hospital were recruited for this study. Clinical outcomes of interest included overall survival (OS), GVHD rates, and failure-free survival (GRFS). The modified PTCy regimen used in this study encompassed the reduction of the dose of cyclophosphamide to 40 mg on days +3 and +4. Patients who had fertility needs were administered a combination of cyclophosphamide, fludarabine, anti-thymocyte globulin (ATG), and total body irradiation (TBI; PTCy-TBI), whereas patients without fertility needs were administered a combination of cyclophosphamide, fludarabine, ATG, and busulfan (PTCy-Bu). Other concurrent therapies, such as GVHD prophylaxis (consisting of PTCy, mycophenolate mofetil, and tacrolimus or cyclosporine A) were administered. “Taken together, the present study suggested that the modified PTCy regimen significantly reduced the incidence of acute GVHD and chronic GVHD in patients who underwent URD HSCT.Among the 30 patients, 6 had very severe aplastic anemia. A total of 21 patients received PTCy-TBI and 9 received PTCy-Bu. The median age of transplantation was 28.5 years and the median time from diagnosis to transplantation was 153 days. Patients who received the modified PTCy regimen for URD HSCT had a relatively long OS, with a 2-year OS of 97%. GRFS was found to be consistent with the OS rate, with a 2-year GRFS of 93%. There was a relatively low cumulative incidence of acute GFVD (grade II) at 13.8%, with no patients developing grade III/IV acute GVHD. Meanwhile, the incidence of chronic GVHD was 10.3%. All the patients who were followed up for more than 18 months no longer required immunosuppressants. “Taken together, the present study suggested that the modified PTCy regimen significantly reduced the incidence of acute GVHD and chronic GVHD in patients who underwent URD HSCT,” the study authors wrote inMK REGIMEN ADVISOR Trademark - Registration Number
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Cisplatin-based combination chemotherapy regimen. Each cycle of induction chemotherapy is administered every 14 days:Methotrexate 30 mg/m2 on day 1.Vinblastine 3 mg/m2 on day 2.Doxorubicin 30 mg/m2 on day 2.Cisplatin 70 mg/m2 on day 2.Myeloid growth factor support therapy for prevention of febrile neutropenia should be initiated on day 3 of each cycle:Filgrastim 5 mcg/kg subcutaneously daily on days 3 through 9, or Pegfilgrastim 6 mg subcutaneously on day 3.Radical cystectomy should be performed between 4 and 10 weeks after completion of the fourth cycle of ddM-VAC. Up to 38% of patients who receive induction cisplatin-based combination chemotherapy do not have residual tumor in the bladder (pathologic complete response) at the time of radical cystectomy. Pathologic complete response at the time of radical cystectomy is associated with improved overall survival and recurrence-free survival.Overall, induction cisplatin-based combination chemotherapy is safe. It does not decrease the patient’s chance of undergoing a radical cystectomy. No treatment related deaths have been reported in published prospective phase III randomized controlled clinical trials. Induction cisplatin-based combination chemotherapy does not increase the rate of postoperative complications. The dose-dense regimen is currently preferred over the prior standard M-VAC regimen due to its improved toxicity profile. Grade 3 neutropenia was the main toxicity and seen in 10% of patients. Ninety-five per cent were able to receive all 4 cycles.2. Gemcitabine plus cisplatin (GC)Gemcitabine plus cisplatin (GC) is a commonly prescribed induction chemotherapy regimen before radical cystectomy for patients with muscle invasive bladder cancer. This regimen includes three cycles of GC administered every 28 days:Gemcitabine 1000 mg/m2 on days 1, 8, and 15Cisplatin 70 mg/m2 on day 2There are no published prospective randomized phase III clinical trials evaluating the safety and efficacy of induction GC followed by radical cystectomy for patients with muscle invasive bladder cancer. Despite this lack of evidence,Mk Regimen Advisor Trademark - Mary Kay Inc. - Bizapedia
ADVANCED (UGLY) risk category rectal cancer (cT3 with any MRF involved, any cT4a/b, lateral node +). a. Upfront surgery b. Short course radiotherapy (SCRT) followed by surgery c. Long-course chemoradiotherapy (LCCRT) followed by surgery d. Total Neoadjuvant Therapy (TNT) If choosing a TNT approach, which protocol would you prefer in this case? a. PRODIGE 23 (FOLFIRINOX – LCCRT – Surgery – FOLFOX) b. RAPIDO or STELLAR (SCRT – FOLFOX or CAPOX – Surgery) c. Induction OPRA or CAO/ARO/AIO-12 (FOLFOX – LCCRT – Surgery) d. Consolidation OPRA or CAO/ARO/AIO-12 (LCCRT – FOLFOX – Surgery) ResultsOne hundred and seventy delegates attended the AICCC including 17 colorectal surgeons (CRS), 7 radiation oncologists (RO) and 21 medical oncologists (MO). Forty-five participants answered at least one question in the survey. Thirteen were excluded from subsequent analysis as they did not specify their specialty. The response rate was therefore 71%. Data was 95% complete for this group.Early riskSeventy-seven percent (24/31) of all specialists preferred an upfront surgery approach whilst neoadjuvant LCCRT and SCRT were preferred by 10% each (Fig. 3A). CRS and RO almost unanimously chose upfront surgery whereas MO were split between upfront surgery (50%) and a form of neoadjuvant radiation (40%) (p = 0.41) (Fig. 3B). Just one participant selected TNT for early-risk rectal cancer.Fig. 3Preferred treatment approaches to ESMO rectal cancer risk categories, A all participants, B–E by specialistFull size imageIntermediate riskThe greatest heterogeneity of responses was observed in this category. Just over half of respondents (16/30) indicated a preference for TNT whilst a third chose LCCRT as the preferred neoadjuvant strategy. Seven percent of specialists opted for SCRT with another 7% preferring upfront surgery. TNT was selected most prominently by MO (71%) whilst LCCRT was most popular amongst RO (57%) and CRS (44%) (p = 0.30) (Fig. 3C).If utilizing a TNT approach, 55% (17/31) selected a consolidation-type (OPRA or CAO/ARO/AIO-12) regimen, 23% a RAPIDO or STELLAR regimen, 16% PRODIGE-23 and 6% an induction-type (OPRA or CAO/ARO/AIO-12) regimen (Fig. 4A). The majority of CRS and RO preferred a consolidation regimen whilst MO were divided between consolidation (40%) and a RAPIDO or STELLAR regimenBeautiful Skin with MK Regimen
For all components of the colonoscopy preparation. Dietary modifications should be limited to the day before colonoscopy and include low-residue, low-fiber foods or full liquids for the early to mid-day meals on the day before colonoscopy when using a split dose bowel preparation. A same-day regimen is an acceptable alternative to split-dosing for those undergoing an afternoon colonoscopy. However, for those individuals undergoing a morning colonoscopy, it is suggested that a same-day regimen is inferior to split-dosing regimen. While the task force does not recommend one bowel preparation purgative as superior to others to achieve adequate bowel preparation, they do suggest utilization of 2 L bowel preparation regimens over 4 L regimens. In addition, it is recommended to take into consideration the patient’s medical history, medications and adequacy of bowel preparation from any prior colonoscopy in their history. The task force recommends against the use of hyperosmotic bowel preparation regimens for those at risk for electrolyte disturbance or volume overload. Adjunctive use of oral simethicone before colonoscopy is suggested while the task force suggests against routine use of non-simethicone adjuncts before colonoscopy.Post-colonoscopy recommendations include routine tracking of adequate bowel preparation rates for individual endoscopists as well as the individual endoscopy unit, and that the adequacy rate meet or exceed 90% as a priority quality performance indicator for colonoscopy. When the bowel preparation is felt to be inadequate to assign standard screening or surveillance intervals, it is recommended to complete a colonoscopy with adequate bowel preparation within 12 months for screening. MK REGIMEN ADVISOR is a trademark of Mary Kay Inc. Filed in June 28 (2025), the MK REGIMEN ADVISOR covers DOWNLOADABLE SOFTWARE APPLICATIONS IN THE Mk Regimen Advisor is a Trademark by Mary Kay Inc, the address on file for this trademark is Dallas Parkway, Addison, TXComments
(33%) (p = 0.42) (Fig. 4B).Fig. 4Preferred TNT regimens for each ESMO rectal cancer risk category, A all participants, B–D by specialistFull size imageBad riskThe proportion of specialists preferring TNT increased for bad-risk rectal cancer as 76% (22/29) favoured TNT compared to 24% for LCCRT. There was no significant difference between CRS, RO and MO—at least 70% of each preferred TNT for this risk category (p = 0.75) (Fig. 3D). The most selected TNT paradigm was again a consolidation-type regimen, chosen by 55% (16/29). Twenty-one percent preferred an induction regimen, 14% PRODIGE-23 and 10% a RAPIDO or STELLAR regimen. The majority (> 60%) of CRS and RO preferred a consolidation TNT strategy whilst MO preferences were again divided across the TNT regimens (p = 0.60) (Fig. 4C).Advanced riskThere was almost an entire agreement amongst participants that TNT was the preferred approach for advanced-risk rectal cancer as selected by 94% (29/31) of specialists, with no significant difference between CRS, RO or MO (p = 0.29) (Fig. 3E). With regard to the preferred TNT sequence, 69% (20/29) opted for a consolidation-type regimen, 14% for a RAPIDO or STELLAR regimen, 10% induction and 7% PRODIGE-23. The majority (> 60%) of each specialty preferred a consolidation regimen (p = 0.98) (Fig. 4D).DiscussionThe majority of specialists in this survey preferred a TNT strategy for advanced- and bad-risk category rectal cancers, which is supported by strong evidence from the major phase 3 TNT trials. Although TNT data has demonstrated improvements in complete response rates and DFS, our study clearly indicates that TNT is not mandated for all patients. In fact, the overwhelming majority of specialists preferred upfront surgery for early-risk, stage II and III rectal tumours. Meanwhile, the intermediate-risk category provoked the most heterogeneous responses from participants although approximately half opted for TNT. Overall, this survey showed that TNT is not a universal approach to LARC but rather a strategy that can be employed selectively to higher-risk patients on an individualized basis.Across the intermediate, bad, and advanced-risk categories, a consolidation-type TNT regimen, such as that employed in the OPRA and CAO/ARO/AIO-12 trials, was consistently preferred in
2025-04-19A modified post-transplant cyclophosphamide (PTCy) regimen with a reduction in dose of 40 mg on days +3 and +4 may be effective in patients with severe aplastic anemia (SAA) undergoing unrelated donor allogeneic hematopoietic stem cell transplantation (URD-HSCT), while reducing the occurrence of graft vs host disease (GVHD), according to a study published in Transplantation and Cellular Therapy. Current guidelines recommend that allo-HSCT be performed from a human leukocyte antigen (HLA)-matched sibling donor; in the event that this is unavailable, treatment with immunosuppressive therapy is first recommended, failure of which allo-HSCT from URDs may be considered. Prior research has shown that the PTCy regimen is effective in reducing the risk of GVHD; furthermore, this regimen is associated with improved prognosis. The study authors sought to assess the clinical outcomes of patients with SAA who received PTCy regimens for the URT HSCT procedure. From July 2019 to June 2022, 30 patients with SAA who underwent URT HSCT and were on a modified PTCy regimen treated at the Guangzhou First People’s Hospital were recruited for this study. Clinical outcomes of interest included overall survival (OS), GVHD rates, and failure-free survival (GRFS). The modified PTCy regimen used in this study encompassed the reduction of the dose of cyclophosphamide to 40 mg on days +3 and +4. Patients who had fertility needs were administered a combination of cyclophosphamide, fludarabine, anti-thymocyte globulin (ATG), and total body irradiation (TBI; PTCy-TBI), whereas patients without fertility needs were administered a combination of cyclophosphamide, fludarabine, ATG, and busulfan (PTCy-Bu). Other concurrent therapies, such as GVHD prophylaxis (consisting of PTCy, mycophenolate mofetil, and tacrolimus or cyclosporine A) were administered. “Taken together, the present study suggested that the modified PTCy regimen significantly reduced the incidence of acute GVHD and chronic GVHD in patients who underwent URD HSCT.Among the 30 patients, 6 had very severe aplastic anemia. A total of 21 patients received PTCy-TBI and 9 received PTCy-Bu. The median age of transplantation was 28.5 years and the median time from diagnosis to transplantation was 153 days. Patients who received the modified PTCy regimen for URD HSCT had a relatively long OS, with a 2-year OS of 97%. GRFS was found to be consistent with the OS rate, with a 2-year GRFS of 93%. There was a relatively low cumulative incidence of acute GFVD (grade II) at 13.8%, with no patients developing grade III/IV acute GVHD. Meanwhile, the incidence of chronic GVHD was 10.3%. All the patients who were followed up for more than 18 months no longer required immunosuppressants. “Taken together, the present study suggested that the modified PTCy regimen significantly reduced the incidence of acute GVHD and chronic GVHD in patients who underwent URD HSCT,” the study authors wrote in
2025-04-07Cisplatin-based combination chemotherapy regimen. Each cycle of induction chemotherapy is administered every 14 days:Methotrexate 30 mg/m2 on day 1.Vinblastine 3 mg/m2 on day 2.Doxorubicin 30 mg/m2 on day 2.Cisplatin 70 mg/m2 on day 2.Myeloid growth factor support therapy for prevention of febrile neutropenia should be initiated on day 3 of each cycle:Filgrastim 5 mcg/kg subcutaneously daily on days 3 through 9, or Pegfilgrastim 6 mg subcutaneously on day 3.Radical cystectomy should be performed between 4 and 10 weeks after completion of the fourth cycle of ddM-VAC. Up to 38% of patients who receive induction cisplatin-based combination chemotherapy do not have residual tumor in the bladder (pathologic complete response) at the time of radical cystectomy. Pathologic complete response at the time of radical cystectomy is associated with improved overall survival and recurrence-free survival.Overall, induction cisplatin-based combination chemotherapy is safe. It does not decrease the patient’s chance of undergoing a radical cystectomy. No treatment related deaths have been reported in published prospective phase III randomized controlled clinical trials. Induction cisplatin-based combination chemotherapy does not increase the rate of postoperative complications. The dose-dense regimen is currently preferred over the prior standard M-VAC regimen due to its improved toxicity profile. Grade 3 neutropenia was the main toxicity and seen in 10% of patients. Ninety-five per cent were able to receive all 4 cycles.2. Gemcitabine plus cisplatin (GC)Gemcitabine plus cisplatin (GC) is a commonly prescribed induction chemotherapy regimen before radical cystectomy for patients with muscle invasive bladder cancer. This regimen includes three cycles of GC administered every 28 days:Gemcitabine 1000 mg/m2 on days 1, 8, and 15Cisplatin 70 mg/m2 on day 2There are no published prospective randomized phase III clinical trials evaluating the safety and efficacy of induction GC followed by radical cystectomy for patients with muscle invasive bladder cancer. Despite this lack of evidence,
2025-04-03ADVANCED (UGLY) risk category rectal cancer (cT3 with any MRF involved, any cT4a/b, lateral node +). a. Upfront surgery b. Short course radiotherapy (SCRT) followed by surgery c. Long-course chemoradiotherapy (LCCRT) followed by surgery d. Total Neoadjuvant Therapy (TNT) If choosing a TNT approach, which protocol would you prefer in this case? a. PRODIGE 23 (FOLFIRINOX – LCCRT – Surgery – FOLFOX) b. RAPIDO or STELLAR (SCRT – FOLFOX or CAPOX – Surgery) c. Induction OPRA or CAO/ARO/AIO-12 (FOLFOX – LCCRT – Surgery) d. Consolidation OPRA or CAO/ARO/AIO-12 (LCCRT – FOLFOX – Surgery) ResultsOne hundred and seventy delegates attended the AICCC including 17 colorectal surgeons (CRS), 7 radiation oncologists (RO) and 21 medical oncologists (MO). Forty-five participants answered at least one question in the survey. Thirteen were excluded from subsequent analysis as they did not specify their specialty. The response rate was therefore 71%. Data was 95% complete for this group.Early riskSeventy-seven percent (24/31) of all specialists preferred an upfront surgery approach whilst neoadjuvant LCCRT and SCRT were preferred by 10% each (Fig. 3A). CRS and RO almost unanimously chose upfront surgery whereas MO were split between upfront surgery (50%) and a form of neoadjuvant radiation (40%) (p = 0.41) (Fig. 3B). Just one participant selected TNT for early-risk rectal cancer.Fig. 3Preferred treatment approaches to ESMO rectal cancer risk categories, A all participants, B–E by specialistFull size imageIntermediate riskThe greatest heterogeneity of responses was observed in this category. Just over half of respondents (16/30) indicated a preference for TNT whilst a third chose LCCRT as the preferred neoadjuvant strategy. Seven percent of specialists opted for SCRT with another 7% preferring upfront surgery. TNT was selected most prominently by MO (71%) whilst LCCRT was most popular amongst RO (57%) and CRS (44%) (p = 0.30) (Fig. 3C).If utilizing a TNT approach, 55% (17/31) selected a consolidation-type (OPRA or CAO/ARO/AIO-12) regimen, 23% a RAPIDO or STELLAR regimen, 16% PRODIGE-23 and 6% an induction-type (OPRA or CAO/ARO/AIO-12) regimen (Fig. 4A). The majority of CRS and RO preferred a consolidation regimen whilst MO were divided between consolidation (40%) and a RAPIDO or STELLAR regimen
2025-03-27